Selected publications from Burton Lab:
Ilin, V. A., Bai, Q., Watson, A. M., Volgushev, M., Burton, E. A. (2021) Mechanism of pacemaker activity in zebrafish DC2/4 dopaminergic neurons. The Journal of Neuroscience. 41:4141–4157
https://pubmed.ncbi.nlm.nih.gov/33731451/
*Van Laar, V. S, *Chen, J., *Zharikov, A. D., Bai, Q., Di Maio, R., Dukes, A. A., Hastings, T. G., Watkins, S. C., Greenamyre, J. T., St. Croix, C. M., and Burton, E. A. (2020) α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo. Redox Biology. 37: 101695 (*equal contribution, joint first authors)
https://pubmed.ncbi.nlm.nih.gov/32905883/
*Xie, W., *Jiao, B., *Bai, Q., *Ilin, V. A., Sun, M., Burton, C. E., Kolodieznyi, D., Calderon, M. J., Stolz, D. B., Opresko, P. L., St. Croix, C. M., Watkins, S. C., Van Houten, B., Bruchez, M. P., and Burton, E. A. (2020) Chemoptogenetic ablation of neuronal mitochondria in vivo with spatiotemporal precision and controllable severity. eLife. 9:e51845 (*equal contribution, joint first authors)
https://pubmed.ncbi.nlm.nih.gov/32180546/
Dukes, A. D., Bai, Q., Van Laar, V. S., Zhou, Y., Ilin, V., David, C. N., Agim, Z. S., Bonkowsky, J. L., Cannon, J. R., Watkins, S. C., St. Croix, C. M., Burton, E. A. and Berman, S. B. (2016) Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP+ exposure. Neurobiology of Disease. 95:238-249 [Burton E. A. and Berman S. B. are joint corresponding authors]
https://www.ncbi.nlm.nih.gov/pubmed/27452482
Zharikov, A., Cannon, J. R., Tapias, V., Bai, Q., Horowitz, M. P., Shah, V., El Ayadi, A., Hastings, T. G., Greenamyre, J. T., Burton, E. A. (2015) shRNA targeting α-synuclein prevents neurodegeneration in a Parkinson’s disease model. Journal of Clinical Investigation. 125(7):2721-2735 [Featured as a “Scientific Show Stopper” with accompanying commentary on JCI website]
https://www.ncbi.nlm.nih.gov/pubmed/26075822
Bai, Q., Parris, R. S., Burton, E. A. (2014) Different Mechanisms Regulate Expression of Zebrafish Myelin P0 in Myelinating Oligodendrocytes and its Induction Following Axonal Injury. J Biol Chem. 289(35):24114-28. [Featured on the cover of the August 29, 2014 issue of JBC]
https://www.ncbi.nlm.nih.gov/pubmed/25028515
Zhou, Y., Cattley, R. T., Cario, C. L., Bai, Q., Burton, E. A. (2014) Quantification of larval zebrafish motor function in multi-well plates using open-source MATLAB applications. Nature Protocols. 9(7):1533-1548 [Featured on the cover of the July 2014 issue of Nature Protocols]
https://www.ncbi.nlm.nih.gov/pubmed/24901738
Bai, Q., Garver, J. A., Hukriede, N. A., Burton, E. A. (2007). Generation of a transgenic zebrafish model of Tauopathy using a novel promoter element derived from the zebrafish eno2 gene. Nucleic Acids Res. 35 (19), 6501-16
https://www.ncbi.nlm.nih.gov/pubmed/17897967
Click here for a full list of publications
Selected collaborative publications (alphabetically by collaborator):
With Ted Allison, University of Alberta in Edmonton, Canada:
Alyenbaawi, H., Kanyo, R., Locskai, L., Kamali-Jami, R., DuVal, M., Bai, Q., Wille, H., Burton, E. A., Allison, W. T. (2021) Seizures are a druggable mechanistic link between TBI and subsequent tauopathy. eLife, 10, e58744, DOI:7554/eLife.58744
With Oliver Bandmann, University of Sheffield, UK:
Watson, L., Keatinge, M., Gegg, M., Bai, Q., Sandulescu, C., Vardi, A., Futerman, A. H., Schapira, A. H. V., Burton, E. A., Bandmann, O. (2019). Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher’s Disease. Neurobiol Dis 127, 563-569.
With Sarah Berman, Department of Neurology, University of Pittsburgh:
Van Laar, V. S., Arnold, B. A., Cassady, S. J., Chu, C. T., Burton, E. A., and Berman, S. B. (2011). Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization. Human Molecular Genetics. 20(5), 927-40
With Kari Fladmark, University of Bergen, Norway:
Frøyset, A.K., Edson, A.J., Gharbi, N., Khan, E.A., Dondorp, D., Bai, Q., Tiraboschi, E., Suster, M.L., Connolly, J.B., Burton, E.A., and Fladmark, K. E. (2018). Astroglial DJ-1 over-expression up-regulates proteins involved in redox regulation and is neuroprotective in vivo. Redox Biology 16: 237-247.
With Tim Greenamyre, Department of Neurology, University of Pittsburgh:
Di Maio R., Hoffman E.K., Rocha E.M., Keeney M.T., Sanders L.H., De Miranda B.R., Zharikov A., Van Laar A., Stepan A.F., Lanz T.A., Kofler J.K., Burton, E.A., Alessi D.R., Hastings T.G., Greenamyre J.T. (2018). LRRK2 activation in idiopathic Parkinson’s disease. Science Translational Medicine 10.
With Jeff Gross, Department of Ophthalmology, University of Pittsburgh:
Hanovice, N. J., Leach, L. L., Slater, K., Gabriel, A. E., Romanovicz, , Shao, E., Collery, R., Burton, E. A., Lathrop, K., Link, B. A., Gross, J. M. (2019). Regeneration of the zebrafish retinal pigment epithelium after widespread genetic ablation. PLOS Genetics. 15(1), e1007939.
With Terri Hastings, Department of Neurology, University of Pittsburgh:
Bucher, M. L., Barrett, C. W., Moon, C. J., Mortimer, A. D., Burton, E. A., Greenamyre, J. T, and Hastings, T. G. (2020). Acquired dysregulation of dopamine homeostasis reproduces features of Parkinson’s disease. NPJ Parkinson’s Disease, 6, 34, DOI: 10.1038/s41531-020-00134-x.